News and Events

The Orthopaedic Research Society has announced this year’s selected podium and poster presenters for the 56th annual meeting, March 2010 in New Orleans.  The Center for Orthopaedic Research and the Department of Orthopaedic Surgery, Columbia University Medical Center are well represented.

Molecular Biomedical Engineering

Aydemir, AB; Minematsu, H ; Gardner, TR ; Kim, KO; Lee, FY: NFAT2 physically interacts with Osterix in response to physiologic mechanical stimulation in human mesenchymal stem cells during osteoblast differentiation - Poster
Blaine, T A; Cote, M A; Ortega, S.; Lee, F Y; Bigliani, L U; Chen, Q: CXCR4 blockade (AMD 3100 and T140 analog) inhibits SDF-1a expression and cell migration in human subacromial bursa cells - Podium
Blaine, T A; Cote, M A; Proto, A; Lee, F Y; Bigliani, L U: Pro-Inflammatory Cytokines Stimulate Stromal Derived Factor-1 (SDF-1α) Expression in Cultured Synoviocytes from Human Subacromial Bursa - Poster
Fong J; Gunja, N; Kim, KO; Lee FY; Hung CT: Comparison of Doxorubicin Resistance of an Osteosarcoma Cell Line in Two and Three Dimensional Cultures – Poster
Kim, KO; Aydemir, AB; Minematsu, H ; Lee, HG ; Gardner, TR ; Ahn JM ; Lee, FY: Transactivation of Cox2 promoter region by NFAT2 in human mesenchymal stem cells in response to tensile strain – Podium
Kim KO, Persaud T, Schiff J, and Lee FY: ERK ½ Inhibition Increases BH3 Domain Proapototic Protein BIM and Apoptosis in osteosarcoma cells - Poster
Lee, HG; Shin, M J; Kim, KO; Patel, N; Aydemir AB; Mikami, M; Minematsu, H; Hung, CT; Lee, FY - Mechanical Perturbations and Metal Particles Exaggerate Bone Resorption and Inflammation in MC3T3E1 Cells  - Podium
Minematsu, H; Shin, M J; Aydemir, ABC; Lee, FY: Nuclear Factor of Activated T Cells (NFAT) regulates innate inflammatory response by Monocyte / Macrophage-lineage cells - Podium
Nair K, Patel N; Staples R, Lee FY: Hyaluronan Gel as a Drug Delivery Vector in Murine Calavarial Osteolysis Models: A New Methodology for Induction of Inflammatory Bone Resorption - Poster
Noh, K C;  Staples, JRW;  Kim, KO; Patel, N; Kim, D; Cha, T;  Seo, SW; Yin, B; Lee, FY: Targeting MAPK/ERK Inflammatory Pathway as a Novel Adjuvant Therapy for Osteosarcoma In vivo – Poster Presentation
Patel, N; Kwak E; Mikami, M; Lee, FY: Cathepsin B Inhibitor CA-074 Me Inhibits Osteoclastogenesis In Vivo and Promotes Calcineurin Cleavage in Murine Bone Marrow-derived Monocyte/macrophage Progenitor Cells - Podium
Patel, N; Lee, JH; Nair, K; Lee, HG; Mikami, M; Staples, JRW, Hielscher, AH Lee, FY Heparin-Regulated controlled release of BSA-Doxorubicin conjugate promotes sarcoma apoptosis: A novel site specific method for treating solid tumors. – Poster
Schiff JC, Kim KO, Lee FY: Paclitaxel induces apoptosis in human osteosarcoma cells – Poster
Shin, MJ; Minematsu, H; Aydemir, ABC; Lee, FY: Constitutive activity of Nuclear Factor of Activated T Cells (NFAT) is essential for LPS-induced Proinflammatory Cytokine Expression in Monocyte/Macrophage-lineage cells - Poster
Staples, JRW; Patel, N; Nair K; Jentry, H; Minematsu, H; Lee FY: Inhibition of
Osteolysis in Mouse Calvarial Bones via Osteoblast Specific ERK1/2 Inhibition In Vivo – Poster

Biomechanics

Fabian, LM; Cassilly, R; Mkparu, A; Gardner, TR; Nwachukwu B; Ahmad, CS; Levine, WN; Teres Minor Hypertrophy Associated with Massive Rotator Cuff Tears Correlates with Active Forward Elevation and Outcomes - Poster
Choi JK; Gardner TR; Yoon, E; Morrison TA; Macaulay W; Geller, JA: A Biomechanical Study in Fixation Techniques on Comminuted Vancouver B1 Periprosthetic Femur Fractures – Poster
Gardner, TR; Cassilly, RT; Jin, B; Ahmad CS; Bigliani, LU; Levine, WN The Effect of Hormone Replacement Therapy on Elongation of the Macaque IGHL – Poster
Moffat, KL; Cassilly, RT; Subramony, SD: Dargis, BR; Liu, XS; Guo, XE; Doty, SB; Levine, WN, Lu, HH - In Vivo Evaluation of a Bi-Phasic Nanofiber-Based Scaffold for Integrative Rotator Cuff Repair – Podium
Yongpravat, C; Dyrszka, MD; Nowak, DD; Gardner, TR; Bigliani LU; Levine, WN; Ahmad, CS: Volume Removed During Total Shoulder Arthroplasty Using 3D Computer Simulation – Poster

Dae Won Kim, MD, recent COR research fellow has accepted an Assistant Professor appointment with Rush University Medical Center, Chicago, Illinois.

Anuli Mparu, MD, Shoulder, Elbow and Sports Medicine, research student 2007-2008, is the winner of the New England Orthopaedic Society 1st Place Kilfoyle Award Competition.

The Department of Orthopaedic Surgery hosted a Multidisciplinary Musculoskeletal Symposium in tribute to Dr. Lee’s research efforts.  The scientific program included prominent guest speakers from the University of Pennsylvania School of Medicine as well as from Columbia University departments of Genetics and Biology, Medicine and Pharmacology, Biomedical Engineering and Orthopaedic Surgery.  It is hoped that this will be the first of many multidisciplinary musculoskeletal scientific exchanges.

Multidisciplinary Musculoskeletal Symposium Program

Dr. Francis Y. Lee associate professor of orthopaedic surgery and director of the Center for Orthopaedic Research has been honored by the Trustees of Columbia University with a tenure appointment in recognition of his outstanding research accomplishments.   Dr. Lee has successfully obtained research funding from the NIH as well as private foundations.  He is one of a select few Columbia University clinician-scientists to warrant the distinction of a tenure appointment.

It is a pleasure to announce that Louis Amorosa, M.D., PGY 3, has been awarded the Resident Trauma Research Support grant from the AO North America Foundation for his proposal The Effect of Mesenchymal & Hematopoietic Stem Cells Loaded into a Tricalcium Phosphate Scaffold in a Rat Femoral Nonunion Model.

Congratulations to Marc Dryszka on placing first place for the best orthopaedic and best overall poster at the 50th Annual National Student Research Forum sponsored by the AMA, Galveston, TX, for Predicting Outcomes of Total Shoulder Arthroplasty Using 3-D Computer Simulations.

We are proud to announce that the National Institutes of Health has awarded Francis Y. Lee, M.D., Ph.D. his second R01 research grant. This is an amazing accomplishment as Dr. Lee is just one of a handful of orthopaedic surgeons to have received R01 funding. The newly awarded grant project will focus on the specific targeting of biomolecular pathways which induce inflammatory bone loss in response to biomaterials. It is hoped that this will lead to the development of clinical effective and safe treatments for inflammatory bone loss due to osteoarthritis, rheumatoid arthritis and orthopaedic and periodontal implants. Additional research projects are currently investigating the molecular mechanisms behind sarcoma bone destruction and chemoresistance.

Dr. Francis Y. Lee is an Associate Professor of Orthopaedic Surgery, College of Physicians and Surgeons, Columbia University. He is the Department of Orthopaedic Surgery’s Vice Chair for Research and the Director of the Center for Orthopaedic Research. Dr. Lee is an orthopaedic surgeon specializing in bone tumors, soft tissue sarcomas, metastatic bone cancers and pediatric orthopaedic surgery. He serves as both researcher and mentor to postdoctoral fellows, residents and students. He is the author or co-author of more than forty-five peer reviewed publications.

Congratulations to Ryan Cassilly on placing first for the best overall clinical science presentation for MRI Evaluation of Teres Minor Hypertrophy and Functional Status in Patients with Massive Rotator Cuff Tears at the 35th Annual Eastern-Atlantic Student Research Forum held in Miami, Florida, February 25 -28 and sponsored by the AMA Foundation.