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Foot & Ankle

Clinical & Basic Science Research

Almost one hundred years ago, Dudley Morton wrote his theories on instability of the first metatarsal in various foot pathologies. Because he compared the feet of humans to that of other primates in an era when some considered evolution to be heresy, his ideas were not widely accepted. In recent decades, modern foot and ankle orthopaedists have resuscitated his theories, and debate has raged in academic circles.

Dr. Greisberg has designed a simple device to measure first ray instability, and has completed the first of a series of studies to critically assess Morton’s theories. Preliminary data has shown increased first ray instability in feet with hallux valgus (bunions), as well as flat feet. 

References

1. Greisberg et al, Foot Ankle Intl, 2010

2. Greisberg et al, In Press 

 

Basic Science Research

Over the past 20 years, orthopaedic trauma specialists like Dr. Greisberg have developed very effective strategies for managing severe lower extremity injuries. Despite excellent surgery and perfect reductions, trauma remains the most common cause of ankle arthritis. While research in the 1990s focused on surgical techniques, 21st century medicine demands we think more like gardeners (cultivating the basic bone and cartilage cells into a healing “mood”) and less like carpenters (who are more focused on how to screw the bones together).

 

Dr. Greisberg began studying programmed cell death, or apoptosis, of cartilage cells more than 10 years ago. He has identified cell death in human cartilage after trauma, and has recently developed a laboratory model for high energy articular fracture. Work has begun to unravel the mysteries of cell death after fractures. Although it will take much time and effort, the ultimate goal is to prevent post-traumatic ankle arthritis!

References

1.      Greisberg, Prince, Chambers, CORR, In Press

2.      Swart, Konopka, Greisberg, In Press

Dr. Greisberg's research projects are funded both by grants from orthopaedic research foundations and from private donations. Anyone interested in donating to this research can call 212-305-5974.

 

 

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