Orthopaedic Research Society 2023 Annual Meeting

The Orthopaedic Research Society (ORS) 2023 Annual Meeting will include lectures and presentations from Columbia Orthopedics faculty and researchers. ORS is an international hub for biologists, engineers, clinicians, surgeon-scientists, orthopaedic surgeons, and veterinarians within the field of musculoskeletal science and orthopaedic care. The meeting will take place on February 10 – 14 in Dallas, Texas.

See below for the syllabus of presentations, lectures, and posters being presented by Columbia Orthopedics faculty and researchers:

Friday, February 10

Grant Writing:

• 8:00am - The Art of Grant Writing Workshop. Nadeen Chahine, PhD (Faculty participant and workshop co-organizer)

ORS Spine Section Scientific Symposium

• 3:00pm - Session 1: Enhancing Spine Research through Leadership, Diversity and Mentoring. Moderators: Nadeen O. Chahine, PhD and Simon Tang, PhD

Saturday, February 11

Podium Session 7 - Intervertebral Disc – Biology

• 11:45am - Paper No. 49 - Intervertebral Disc Activation Of NF-κB Leads To Systemic Inflammation And Disc Macrophage Infiltration. (Authors: Mark (Min Kyu) Kim; Kevin Burt; Nadeen O. Chahine)

Monday, February 13

Scientific Sessions - Tendon Development, Differentiation and Healing

• 3:15pm - Derivation of Fibrous Connective Tissue Lineages from Pluripotent Stem Cells. Alice H. Huang

Posters

Cartilage and Synovium - Function, Structure and Mechanics

• Poster No. 591 - Hyperglycemic Culture Conditions Alters The Functional And Mechanical Properties Of Synovium In The Progression Of Diabetic Osteoarthritis. (Authors: Neeraj Sakhrani; Lianna Gangi; Hagar Kenawy; Ratna Sharma; Roshan P, Shah; Nadeen O. Chahine; Gerard Ateshian; Clark Hung)

Cartilage and Synovium - Treatment and Therapeutics

• Poster No. 621 - Maintaining Chondrocyte Viability In The Processing Of Bendable Osteochondral Allografts. (Authors: Katherine A. Spack; Courtney A. Petersen; Peter T. Shyu; Chantelle C. Bozynski; Mary K. Romesburg; X. Edward Guo; James T. Cook; Clark T. Hung; Melvin P. Rosenwasser; Gerard A. Ateshian)

Intervertebral Disc - Diseases and Disorders

• Poster No. 918 - Intradiscal Inflammatory Stimulation Induces Spinal Pain Behavior And Intervertebral Disc Degeneration In Vivo. (Authors: Lauren Lisiewski; Hayley Jacobsen; Dan Viola; Hagar Kenawy; Daniel Kiridly; Nadeen O. Chahine)

Intervertebral Disc - Structure, Function and Mechanics

• Poster No. 928 - Secretome Of Mechanically Loaded Intervertebral Discs Influences Stem Cell Immunomodulatory Response. (Authors: Hagar M. Kenawy; Lauren E. Lisiewski; Clark T. Hung; Nadeen O. Chahine)

Intervertebral Disc - Treatment and Therapeutics

• Poster No. 936 - TGF-b3-Releasing Bioinstructive Constructs Promote AF- And NP-like IVD Cell Phenotypes In 3D Printed Scaffolds. (Authors: Lauren Lisiewski; Jessica Liu; Sarah Liu; Helen Lu; Nadeen O. Chahine)

Tendon and Ligament - Growth, Development and Aging

• Poster No. 1128 - Primary Cilia Regulate Tendon Enthesis Stem Cell Mechanoresponsiveness During Development. (Authors: Matthew Casserly; Stavros A. Thomopoulos; Fei Fang)
• Poster No. 1129 - Crosstalk Between Hematopoietic And Mesenchymal Lineage Cells In The Developing Enthesis. (Authors: Valia P. Leifer; Fei Fang; Lee Song; Stavros A. Thomopoulos)

Tendon and Ligament - Injury and Healing

• Poster No. 1134 - Establishing Catwalk XT Gait Parameters For Mouse Achilles Tendon Injury And Healing. (Authors: Giulia Crosio; Alice H. Huang)
• Poster No. 1138 - The Specificity And Therapeutic Potential Of Enthesis Gli1-Lineage Cells For Enthesis Repair. (Authors: Fei Fang; Stavros A. Thomopoulos)
• Poster No. 1140 - The Role Of IL33 In Tendon Healing And Inflammation. (Authors: Giulia Crosio; Alice H. Huang; Varun Arvind)

Cartilage and Synovium - Treatment and Therapeutics

• Poster No. 1440 - Bendable Osteochondral Allografts For Patellar Resurfacing: A Cadaveric Analysis Of Congruence. (Authors: Katherine A. Spack; Courtney A. Petersen; Peter T. Shyu; X. Edward Guo; Thomas R. Gardner; James L. Cook; Clark T. Hung; Melvin P. Rosenwasser; Gerard A. Ateshian)

Hip and Knee Arthroplasty - Clinical Outcomes

• Poster No. 1610 - The Effectiveness Of Lipped Acetabular Liners In Anterior Total Hip Arthroplasty On Instability 161. (Authors: Joseph Genualdi; Alaka Gorur; Matthew LaVelle; Roshan P. Shah; Alexander L. Neuwirth; H. John Cooper; Jeffrey A. Geller)

Intervertebral Disc - Injury, Healing and Pain

• Poster No. 1741 - HMGB1 Mediates Macrophage Recruitment And Regional Intervertebral Disc Properties Following Injury. (Authors: Kevin Burt; Mark (Min Kyu) Kim; Dan Viola; Gerard Marciano; Joseph Genualdi; Clark Hung; Nadeen O. Chahine)

Tendon and Ligament -Injury and Healing

• Poster No. 1967 - IKK-β Inhibition Facilitates Early Healing Following Intrasynovial Tendon Repair In A Canine Model. (Authors: Ryan A. Lane; Richard H. Gelberman; Hua Shen; Shelly E. Sakiyama-Elbert; Stavros A. Thomopoulos)
• Poster No. 1968 - ASC Activation By Macrophages And Tendon Fibroblasts. (Authors: Astia Innis; David Roberts; Brittany Marshall; Lee Song; Stavros A. Thomopoulos)
• Poster No. 1970 - Ferroptosis As A Potential Mechanism For Blood-induced Cell Death In ACL Injury. (Authors: Howard Nicholson; Andy Lee; Neeraj Sakhrani; Beth G. Ashinsky; Stavros A. Thomopoulos; Gerard A. Ateshian; Clark T. Hung)

Late Breaking Poster Session 1

• Poster No. 2068 - Sex-based Differences In The Interleukin-1β Response Of Tissue-engineered Cartilage. (Authors: Maria I. Nunez; Hagar M. Kenawy; Lianna R. Gangi; Aaron M. Stoker; James L. Cook; Gerard A. Ateshian; Nadeen O. Chahine; Clark T. Hung)

Late Breaking Poster Session 2

• Poster No. 2272 - Characterizing The Cell Phenotypes Of The Anterior Cruciate Ligament Sheath: Implications For Repair Strategies. (Authors: Beth G. Ashinsky; James Rogot; Minkyu M. Kim; McKenzie E. Sup; Roshan P. Shah; Nadeen O. Chahine; Clark T. Hung; Stavros A. Thomopoulos)